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  • Human ACE2 (His tag) recombinant protein

Human ACE2 (His tag) recombinant protein

Cat.#: 521000

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Product Information

  • Product Name
    Human ACE2 (His tag) recombinant protein
  • Documents
  • Description
    Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
  • Protein short names
    ACE2; ACEH; DKFZP434A014; RP23-330O24.1; 2010305L05RIK
  • Uniprot ID
    Q9BYF1
  • Gene Name
    ACE2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Ser 740) of human ACE2 precursor (NP_068576.1) was expressed with the 6His tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    85.1 kDa
  • Purity
    > 95 % as determined by SDS-PAGE.
    > 90 % as determined by SEC-HPLC
  • Activity
    1. Measured by binding Spike RBD in a functional ELISA.
    Immobilized SARS-CoV-2 Spike RBD Protein (Fc Tag, 521009) at 1μg/mL (100μL/well) can bind human ACE2 protein (His tag, 521000), the EC50 of ACE2 is 10-25 ng/mL.
    2. Measured by cleaving McaYVADAPK (Dnp)OH
    Reacted with the fluorogenic peptide substrate McaYVADAPK (Dnp)OH, Catalog # ES007 from R&D Systems. The specific activity is >1000 pmols/min/μg.
  • Validations

    Human ACE2 (His tag) recombinant protein

    Human ACE2 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"