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  • Anti-ACE2 / Angiotensin-Converting Enzyme 2 antibody
  • Anti-ACE2 / Angiotensin-Converting Enzyme 2 antibody

Anti-ACE2 / Angiotensin-Converting Enzyme 2 antibody

Cat.#: 106360

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Product Information

  • Product Name
    Anti-ACE2 / Angiotensin-Converting Enzyme 2 antibody
  • Documents
  • Description
    Rabbit monoclonal to ACE2 / Angiotensin-Converting Enzyme 2
  • Tested applications
    IHC-P
  • Species reactivity
    Rat ACE2
  • Alternative names
    ACEH antibody; 2010305L05Rik antibody; 2010305L05Rik antibody; ACE2 antibody; Ace2 antibody; ACEH antibody; DKFZp434A014 antibody; RP23-330O24.1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Rat ACE2 (rR ACE2; Q5EGZ1; Met1-Thr740).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 1-10 μg/mL

  • Validations

    ACE2 / Angiotensin-Converting Enzyme 2 Antibody, Rabbit MAb, Immunohistochemistry

    ACE2 / Angiotensin-Converting Enzyme 2 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of rat ACE2 in rat esophagus with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).

    ACE2 / Angiotensin-Converting Enzyme 2 Antibody, Rabbit MAb, Immunohistochemistry

    ACE2 / Angiotensin-Converting Enzyme 2 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of rat ACE2 in rat lung with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.
  • References
    • Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.
    • Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.
    • Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.
    • Turner AJ, et al. (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 25(6): 291-4.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"