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Product Name
Rat ACE2 / Angiotensin-Converting Enzyme 2 (His Tag) recombinant protein
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Description
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.
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Protein name
Angiotensin-converting enzyme 2
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Protein short names
RP23-330O24.1; 2010305L05RIK; ACE2; ACEH; DKFZP434A014
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Uniprot ID
Q5EGZ1
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Gene Name
Ace2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat ACE2 (Q5EGZ1) extracellular domain (Met 1-Thr 740) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat ACE2 comprises 734 amino acids and predicts a molecular mass of 85 kDa. The apparent molecular mass of the rat ACE2 is approximately 105-115 kDa in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave a fluorogenic peptide substrate, Mca-YVADAPK(Dnp)-OH, (R&D Systems, Catalog # ES007). The specific activity is >300 pmol/min/μg.
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Validations
Rat ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) SDS-PAGE
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