Rat Junctional Adhesion Molecule B (Fc Tag) recombinant protein

Cat.#: 501023

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Product Information

  • Product Name
    Rat Junctional Adhesion Molecule B (Fc Tag) recombinant protein
  • Documents
  • Description
    Junctional adhesion molecule B (JAM-B), also known as Junctional adhesion molecule 2 (JAM2), Vascular endothelial junction-associated molecule (VE-JAM), and CD322, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is prominently expressed on high endothelial venules. expression to be restricted to the high endothelial venule of tonsil and lymph nodes. The localization to the endothelium of arterioles in and around inflammatory and tumor foci. JAM-B can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56(+) NK cells, circulating CD56(+)CD3(+) NK/T cells, and circulating CD56(+)CD3(+)CD8(+) cytolytic T cells. JAM-2 is expressed on high endothelial venules (HEVs) in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration. It binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1. JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
  • Protein name
    Junctional adhesion molecule 2
  • Protein short names
    JAM-B; UNQ219/PRO245; JAM-2; 2410030G21RIK; JAM2; PRO245; C21ORF43; JAM-IT/VE-JAM; 1110002N23RIK; JCAM2; JAMB; CD322; VEJAM; RP23-253E17.2; 2410167M24RIK; VE-JAM; AU016127
  • Uniprot ID
    Q3MHC0
  • Gene Name
    Jam2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat JAM2 (Q3MHC0) (Met1-Asn236) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat JAM2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 449 amino acids and has a predicted molecular mass of 50.3 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Rat JAM-2 / JAM-B Protein (Fc Tag) SDS-PAGE

    Rat JAM-2 / JAM-B Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"