Human IL1RL1 (Fc Tag) recombinant protein
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
Interleukin-1 receptor-like 1
Protein short names
DER4; T1/ST2; T1; IL33R; ST2V; ST2; MGC32623; IL1RL1; ST2L; ST2-RS1; LY84; FIT-1
IL1RL1; DER4; ST2; T1
A DNA sequence encoding the human IL1RL1 isoform 2 (NP_003847.2) (Met 1-Phe 328) was fused with the Fc region of human IgG1 at the C-terminus.
The recombinant human IL1RL1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 548 amino acids and has a calculated molecular mass of 67.1 kDa. As a result of glycosylation, the apparent molecular mass of rh IL1RL1/Fc monomer is approximately 85-95 kDa in SDS-PAGE under reducing conditions.
> 95 % as determined by SDS-PAGE
Measured by its binding ability in a functional ELISA. Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 / Fc Chimera with a linear range of 0.31-5 ng/ml.
Human IL1RL1 / DER4 Protein (Fc Tag) SDS-PAGE
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