-
Product Name
Human SAE1 recombinant protein
- Documents
-
Description
SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL1. SAE1 binds with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1. SAE1 also regulates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.
-
Protein name
SUMO-activating enzyme subunit 1
-
Protein short names
UBLE1A; UBIQUITIN-LIKE (SENTRIN) ACTIVATING ENZYME E1A; SUMO-ACTIVATING ENZYME SUBUNIT 1; 2400010M20RIK; AW743391; HSPC140; UBIQUITIN-LIKE 1 (SENTRIN) ACTIVATING ENZYME E1A; SUMO-1 ACTIVATING ENZYME E1 N SUBUNIT; UBIQUITIN-LIKE 1-ACTIVATING ENZYME E1A; D7ERTD177E; SENTRIN/SUMO-ACTIVATING PROTEIN AOS1; UBIQUITIN-LIKE PROTEIN SUMO-1 ACTIVATING ENZYME; ACTIVATOR OF SUMO1; SUA1; 2610044L12RIK; AOS1; UBIQUITIN-LIKE 1 (SENTRIN) ACTIVATING ENZYME SUBUNIT 1; SUMO-1 ACTIVATING ENZYME SUBUNIT 1; AL033372
-
Uniprot ID
Q9UBE0
-
Gene Name
SAE1; AOS1; SUA1; UBLE1A
-
Source/Expression Host
Baculovirus-Insect Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human SAE1 (Q9UBE0) (Met1-Lys346) was expressed and purified.
-
Protein Species
Human
-
Molecular weight
The recombinant human CRIP2 consists of 348 amino acids and predicts a molecular mass of 38.6 KDa. It migrates as an approximately 39 KDa band in SDS-PAGE under reducing conditions.
-
Purity
> 95 % as determined by SDS-PAGE
-
Validations
Human SAE1 Protein SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"