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Product Name
Human NRG1/GGF/HGL/HRGA/NDF/SMDF (His tag) recombinant protein
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Description
neuregulin-1 (heregulin-1，NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
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Protein name
neuregulin 1(NRG1)
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Protein short names
GGF; HGL; HRGA; NDF; SMDF
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Uniprot ID
Q02297-6
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human NRG1/GGF/HGL/HRGA/NDF/SMDF Met1-Lys246 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human NRG1/GGF/HGL/HRGA/NDF/SMDF (His tag) recombinant protein
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