Human NRG1 (EGF Domain, Fc Tag) recombinant protein

Human NRG1 (EGF Domain, Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. 

Pro-neuregulin-1, membrane-bound isoform

MSTP131; HRG1; GGF; MST131; GGFII; SMDF; NRG1-IT2; HRG; NDF; HGL; ARIA; HRGALPHA; HRGA; D230005F13RIK; GGF2; 6030402G23RIK

Q02297

NRG1; GGF; HGL; HRGA; NDF; SMDF

Human Cells

A DNA sequence encoding the EGF-like domain (Thr 176-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was fused with the Fc region of human IgG1 at the N-terminus.

Human

The recombinant human NRG1?aa176-246?/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 331 amino acids and has a calculated molecular mass of 36.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NRG1/Fc monomer is approximately 38 kDa.

> 86 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized Rhesus ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1), The EC₅₀ of human NRG1 (isoform Beta1) is 0.58 μg/mL.
3. Immobilized human ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1), The EC₅₀ of human NRG1 (isoform Beta1) is 0.43 μg/mL.