Human NRG1 (Fc Tag) recombinant protein

Human NRG1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. 

Pro-neuregulin-1, membrane-bound isoform

6030402G23RIK; GGF2; D230005F13RIK; HRGALPHA; HRGA; ARIA; HGL; NDF; HRG; NRG1-IT2; GGFII; SMDF; MST131; GGF; MSTP131; HRG1

Q02297

NRG1; GGF; HGL; HRGA; NDF; SMDF

Human Cells

A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.

Human

The recombinant human NRG1/mFc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 88 % as determined by SDS-PAGE

1. Measured by its ability to bind with human ErbB4-His (Cat:503994) in a functional ELISA.
2. Measured by its ability to bind with human ErbB3-His (Cat:503568) in a functional ELISA.