-
Product Name
Human NRG1 (Fc Tag) recombinant protein
- Documents
-
Description
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
-
Protein name
Pro-neuregulin-1, membrane-bound isoform
-
Protein short names
D230005F13RIK; GGF2; 6030402G23RIK; NDF; HGL; ARIA; HRGA; HRGALPHA; NRG1-IT2; SMDF; GGFII; HRG; HRG1; MSTP131; GGF; MST131
-
Uniprot ID
Q6PK61
-
Gene Name
NRG1; GGF; HGL; HRGA; NDF; SMDF
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human NRG1 (NP_001153480.1) (Ser177-Gln237) was expressed with the Fc region of human IgG1 at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human NRG1 consists 321 amino acids and predicts a molecular mass of 35.5 kDa.
-
Purity
> 90 % as determined by SDS-PAGE.
-
Validations
NRG1 protein SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"