Human NRG1/GGF/HGL/HRGA/NDF/SMDF recombinant protein

Cat.#: 518840

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Product Information

  • Product Name
    Human NRG1/GGF/HGL/HRGA/NDF/SMDF recombinant protein
  • Documents
  • Description
    Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
  • Protein name
    neuregulin 1(NRG1)
  • Protein short names
    GGF; HGL; HRGA; NDF; SMDF
  • Uniprot ID
    Q02297-6
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human NRG1/GGF/HGL/HRGA/NDF/SMDF Ser2-Lys246 is expressed.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human NRG1/GGF/HGL/HRGA/NDF/SMDF recombinant protein

    Human NRG1/GGF/HGL/HRGA/NDF/SMDF recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"