Human NRG1 recombinant protein

Human NRG1 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Pro-neuregulin-1, membrane-bound isoform

MST131; GGF; HRG1; MSTP131; HRG; NRG1-IT2; GGFII; SMDF; HRGA; HRGALPHA; ARIA; HGL; NDF; 6030402G23RIK; GGF2; D230005F13RIK

Q02297

NRG1; GGF; HGL; HRGA; NDF; SMDF

Human Cells

A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed.

Human

The recombinant human NRG1 comprises 245 amino acids and has a predicted molecular mass of 26.8 kDa.

> 90 % as determined by SDS-PAGE

Measured in a cell proliferation assay using MCF-7 cells.
The ED₅₀ for this effect is typically 2-10 ng/mL.