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Product Name
Human NKG2A & CD94 (His & Flag tag) recombinant protein
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Description
NKG2-A/NKG2-B Type II Integral Membrane Protein contains 1 C-type lectin domain and belongs to the killer cell lectin-like receptor family. The killer cell lectin-like receptor family is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of natural killer cells in the innate immune system. CD94 Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. CD94 Can form disulfide-bonded heterodimer with NKG2 family members. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.
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Protein name
NKG2A & CD94 Heterodimer
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Uniprot ID
P26715&Q13241
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human NKG2A & CD94 Arg100-Leu233 & Ser34-Ile179 is expressedwith a 8His & Flag tag at the N-terminus
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human NKG2A & CD94 (His & Flag tag) recombinant protein
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