-
Product Name
Anti-NKG2A / NKG2 / CD159A / KLRC1 antibody
- Documents
-
Description
Rabbit polyclonal to NKG2A / NKG2 / CD159A / KLRC1
-
Tested applications
ELISA, WB
-
Species reactivity
Mouse NKG2A / NKG2 / CD159A / KLRC1
-
Alternative names
CD159 antigen-like family member A antibody; CD159A antibody; CD159a antibody; C-lectin type II protein antibody; MGC13374 antibody; MGC59791 antibody; natural killer cell lectin antibody; natural killer group protein 2 antibody; NK cell receptor A antibody; NKG2 antibody; NKG2-1/B activating NK receptor antibody; NKG2A antibody; NKG2A antibody; NKG2-A/B type II integral membrane protein antibody; NKG2-A/B-activating NK receptor antibody; NKG2-A/NKG2-B type II integral membrane protein antibody; NKG2-A/NKG2-B type II integral membrane protein antibody; NKG2B antibody; NKG2 antibody; NKG2A antibody; CD159A antibody; NKG2A antibody; NKG2B antibody; CD159a antibody
- Immunogen
-
Isotype
Rabbit IgG
-
Preparation
Produced in rabbits immunized with purified, recombinant Mouse NKG2A / NKG2 / CD159A / KLRC1 (rM NKG2A / NKG2 / CD159A / KLRC1; AAD24969.1; Ala94-Ile244). NKG2A / NKG2 / CD159A / KLRC1 specific IgG was purified by Mouse NKG2A / NKG2 / CD159A / KLRC1 affinity chromatography.
-
Clonality
Polyclonal
-
Formulation
0.2 μm filtered solution in PBS
-
Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/ml
ELISA: 0.1-0.2 μg/ml
This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Mouse NKG2A / NKG2 / CD159A / KLRC1.
-
Validations
NKG2A / NKG2 / CD159A / KLRC1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
-
Background
NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this fmaily are characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2 contains 1 C-type lectin domain and forms a complex with another family member, KLRD1/CD94. It is expressed only in NK-cells, but not in T-cells or B-cells. It has been shown that NKG2 represents a family of related cDNA clones, designated NKG2A, NKG2B, NKG2C, and NKG2D, which encode type 2 integral membrane proteins (extracellular C-terminus) containing a C-type lectin domain. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NKG2 functions as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
-
References
- Angelini DF, et al. (2011) NKG2A inhibits NKG2C effector functions of gamma delta T cells: implications in health and disease. J Leukoc Biol. 89(1):75-84.
- Ge SJ, et al. (2011) Expression of NKG2D and NKG2A with their ligands MHC-I A/B and HLA-E in acute leukemia patients and its significance. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 19(2):312-6.
- Ablamunits V, et al. (2011) NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti-CD3 antibody. Eur J Immunol. 41(7):1832-42.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"