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  • Human N-Cadherin/CD325/CDH2 (His Tag) recombinant protein

Human N-Cadherin/CD325/CDH2 (His Tag) recombinant protein

Cat.#: 503468

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Product Information

  • Product Name
    Human N-Cadherin/CD325/CDH2 (His Tag) recombinant protein
  • Documents
  • Description
    Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.
  • Protein name
    Cadherin 2, type 1, N-cadherin (Neuronal), isoform CRA_b
  • Protein short names
    CDH2; CDW325; NCAD; N-CADHERIN; CADHERIN 2; CD325; N-CADHERIN 1; NEURAL CADHERIN; CADHERIN-2; CDHN; OTTMUSP00000017505
  • Uniprot ID
    P19022
  • Gene Name
    CDH2; hCG_22518
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CDH2 (NP_001783.2) (Met1-Ala724) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CDH2 consists 710 amino acids and predicts a molecular mass of 78.5 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Human N-Cadherin / CD325 / CDH2 Protein (His Tag)

    Human N-Cadherin / CD325 / CDH2 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"