Human Cadherin-12/CDH12 (His Tag) recombinant protein

Human Cadherin-12/CDH12 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.

Cadherin 2, type 1, N-cadherin (Neuronal), isoform CRA_b

CDH2; CDW325; NCAD; N-CADHERIN; CADHERIN 2; CD325; N-CADHERIN 1; NEURAL CADHERIN; CADHERIN-2; CDHN; OTTMUSP00000017505

P19022

CDH2; hCG_22518

Human Cells

A DNA sequence encoding the pro form of human CDH12 (NP_001783.2) extracellular domain (Met 1-Ala 605) was fused with a polyhistidine tag at the C-terminus.

Human

The recombinant human CDH12 comprises 593 amino acids and has a predicted molecular mass of 66 kDa. The apparent molecular mass of rhCDH12 is approximately 80-85 kDa in SDS-PAGE due to glycosylation.

> 80 % as determined by SDS-PAGE