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Product Name
Anti-N Cadherin Rabbit antibody
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Description
N Cadherin Rabbit polyclonal antibody
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Tested applications
WB, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
CDHN; NCAD; CD325; CDw325 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human N Cadherin
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
FC: 1/100
IP: 1/20
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Validations
Western blot detection of N Cadherin in HepG2 cell lysates using N Cadherin Rabbit pAb(1:1000 diluted).Predicted band size:100KDa.Observed band size:140KDa.
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Background
Swiss-Prot Acc.P19022.Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"