Human KIT/SCFR (His tag) recombinant protein

Human KIT/SCFR (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. Mature human SCF R consists of a 499 amino acid (aa) extracellular domain (ECD) with five tandem immunoglobulinlike domains, a 21 aa transmembrane segment, and a 431 aa cytoplasmic domain with the split tyrosine kinase domain. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-or Th17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

KIT proto-oncogene receptor tyrosine kinase(KIT)

SCFR

P10721

Human Cells

A DNA sequence encoding the Human KIT/SCFR Gln26-Thr520 is expressed with a 6His at the C-terminus.

Human

>95% as determined by SDS-PAGE.