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Product Name
Human EPOR & CD131 Homodimer Protein
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Protein name
Erythropoietin receptor
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Uniprot ID
P19235
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Gene Name
EPOR
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Pro 250) of human EPOR (NP_000112.1) linked with the extracellular domain (Trp 17-Trp 443) of human CD131 (NP_000386.1) by a peptide linker was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human EPOR&CD131/Fc chimera is a disulfide-linked homodimer of EPOR&CD131-Fc heterodimer. The reduced EPOR& CD131-Fc comprises 906 amino acids and has a calculated molecular mass of 101 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 125 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
1. Measured by its ability to bind rat EPO-His (Cat:502642) in a functional ELISA.
2. Measured by its ability to bind mouse EPO-His (Cat:504106) in a functional ELISA. -
Validations
Human EPOR & CD131 Homodimer Protein SDS-PAGE
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