Anti-EPOR/Erythropoietin Receptor antibody

Cat.#: 101272

Size:

Special Price 193.4 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-EPOR/Erythropoietin Receptor antibody
  • Documents
  • Description
    Rabbit monoclonal to EPOR/Erythropoietin Receptor
  • Tested applications
    FCM
  • Species reactivity
    Human EPOR / Erythropoietin Receptor
  • Alternative names
    EPO R antibody; EPO Receptor antibody; EPOR antibody; Erythropoietin Receptor antibody; EPO-R antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human EPOR / Erythropoietin Receptor (rh EPOR / Erythropoietin Receptor; NP_000112.1; Met1-Pro250).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    FCM: 0.5-2 μg/Test

  • Validations

    EPOR / Erythropoietin Receptor Antibody, Rabbit MAb, Flow Cytometry

    EPOR / Erythropoietin Receptor Antibody, Rabbit MAb, Flow Cytometry

    Profile of anti-Epo R reactivity on TF-1 cells analyzed by flow cytometry.

  • Background
    Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type â…  single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.
  • References
    • Divoky V, et al. (2002) Mouse surviving solely on human erythropoietin receptor (EpoR): model of human EpoR-linked disease. Blood 99(10): 3873-4.
    • Carruthers SG. (2009) A truncated erythropoietin receptor EPOR-T is associated with hypertension susceptibility. Clin Pharmacol Ther. 86(2): 134-6.
    • Baltaziak M, et al. (2009) Relationships of P53 and Bak with EPO and EPOR in human colorectal cancer. Anticancer Res. 29(10):4151-6.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"