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Human EPOR/Erythropoietin Receptor (His Tag) recombinant protein

Cat.#: 502594

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Product Information

  • Product Name
    Human EPOR/Erythropoietin Receptor (His Tag) recombinant protein
  • Documents
  • Description
    Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
  • Protein name
    Erythropoietin receptor
  • Protein short names
    EPOR; EPO R; EPO-R; ERYTHROPOIETIN RECEPTOR; EPO RECEPTOR
  • Uniprot ID
    P19235
  • Gene Name
    EPOR
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Pro 250) of human erythropoietin receptor (NP_000112.1) precursor was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human EPOR consists of 237 amino acids and has a predicted molecular mass of 26.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhEPOR is approximately 34 kDa due to glycosylation.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit EPOdependent proliferation of TF-1 human erythroleukemic cells.
    The ED50 for this effect is typically 15-60 ng/mL in the presence of 0.1 U/mL Recombinant Human EPO.
  • Validations

    Human EPO Receptor / EPOR Protein (His Tag) SDS-PAGE

    Human EPO Receptor / EPOR Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"