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Product Name
Human CD44/LHR/MDU2/MDU3/MIC4 (Fc tag) recombinant protein
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Description
CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.
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Protein name
CD44 molecule (Indian blood group)(CD44)
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Protein short names
LHR; MDU2; MDU3; MIC4
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Uniprot ID
P16070
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human CD44/LHR/MDU2/MDU3/MIC4 Gln21-Pro220 is expressed with a Fc tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human CD44/LHR/MDU2/MDU3/MIC4 (Fc tag) recombinant protein
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