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Human CD44 (His Tag) recombinant protein

Cat.#: 500618

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Special Price 532.2 USD

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Product Information

  • Product Name
    Human CD44 (His Tag) recombinant protein
  • Documents
  • Description
    CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.
  • Protein name
    CD44 antigen
  • Protein short names
    HUTCH-I; HCELL; MDU3; CD44; IN; MDU2; AW121933; MC56; HERMES; ECMR-III; MIC4; LHR; AU023126; LY-24; CDW44; AW146109; AL133330.1; PGP-1; PGP1; MGC10468; RP23-203N8.3; CSPG8
  • Uniprot ID
    P16070
  • Gene Name
    CD44; LHR; MDU2; MDU3; MIC4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the N-terminal fragment (Met 1-Pro 220) of human CD44 (P16070-1) extracellular domain was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CD44 consists of 211 amino acids and has a predicted molecular mass of 23.4 kDa. As a result of glycosylation, the apparent molecular mass of rhCD44 is approximately 43-48 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human CD44 Protein (His Tag) SDS-PAGE

    Human CD44 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"