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  • FKBP52 antibody
  • FKBP52 antibody
  • FKBP52 antibody

FKBP52 antibody

Cat.#: 110677

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Special Price 239.0 USD

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Product Information

  • Product Name
    FKBP52 antibody
  • Documents
  • Description
    FKBP52 Rabbit Polyclonal antibody. Positive IHC detected in human colon tissue, human kidney tissue. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 52 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    51 kDa FK506 binding protein antibody; 52 kDa FK506 binding protein antibody; 52 kDa FKBP antibody; 59 kDa immunophilin antibody; FK506 binding protein 4 antibody; FK506 binding protein 4 antibody; 59kDa antibody; FKBP 4 antibody; FKBP 52 antibody; FKBP4 antibody; FKBP51 antibody; FKBP52 antibody; FKBP59 antibody; HBI antibody; HSP binding immunophilin antibody; Hsp56 antibody; Immunophilin FKBP52 antibody; p52 antibody; p59 antibody; PPIase antibody; PPIase FKBP4 antibody; Rotamase antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of FKBP52 recombinant protein (Accession Number: BC007924). Purification method: Antigen Affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:110677(FKBP52 antibody) at dilution of 1:1000

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:110677(FKBP52 antibody) at dilution of 1:1000

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:110677(FKBP52 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:110677(FKBP52 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:110677(FKBP52 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:110677(FKBP52 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    The large molecular-weight immunophilin, FKBP52, is a known target of the immunosuppressive drug FK506. FKBP52 exhibits peptidyl-prolyl cis–trans isomerase (PPIase) activity, which is inhibited by the binding of FK506—properties that it shares with the smaller but better-studied immunophilin, FKBP12(PMID:15381148). It is essential to AR-mediated induction of genes involved in sexually dimorphic development of the penis (NKX3-1), in erectile function of the mature organ (NOS2 and NOS3), and in promotion of apoptosis during development(PMID:20605780).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"