FKBP52 Rabbit Polyclonal antibody. Positive IHC detected in human colon tissue, human kidney tissue. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 52 kDa
ELISA, WB, IHC
Human; other species not tested.
51 kDa FK506 binding protein antibody; 52 kDa FK506 binding protein antibody; 52 kDa FKBP antibody; 59 kDa immunophilin antibody; FK506 binding protein 4 antibody; FK506 binding protein 4 antibody; 59kDa antibody; FKBP 4 antibody; FKBP 52 antibody; FKBP4 antibody; FKBP51 antibody; FKBP52 antibody; FKBP59 antibody; HBI antibody; HSP binding immunophilin antibody; Hsp56 antibody; Immunophilin FKBP52 antibody; p52 antibody; p59 antibody; PPIase antibody; PPIase FKBP4 antibody; Rotamase antibody
This antibody was obtained by immunization of FKBP52 recombinant protein (Accession Number: BC007924). Purification method: Antigen Affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:110677(FKBP52 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:110677(FKBP52 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:110677(FKBP52 Antibody) at dilution of 1:50 (under 40x lens)
The large molecular-weight immunophilin, FKBP52, is a known target of the immunosuppressive drug FK506. FKBP52 exhibits peptidyl-prolyl cis–trans isomerase (PPIase) activity, which is inhibited by the binding of FK506—properties that it shares with the smaller but better-studied immunophilin, FKBP12(PMID:15381148). It is essential to AR-mediated induction of genes involved in sexually dimorphic development of the penis (NKX3-1), in erectile function of the mature organ (NOS2 and NOS3), and in promotion of apoptosis during development(PMID:20605780).
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