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Product Name
FKBP52 antibody
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Description
FKBP52 Mouse Monoclonal antibody. Positive IF detected in Hela. Positive IHC detected in human appendix. Positive WB detected in K562 cell. Observed molecular weight by Western-blot: 56kD
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
human; other species not tested.
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Alternative names
FKBP4 antibody; FK506 binding protein 4 antibody; 59kDa antibody; FK506 binding protein 4 antibody; 59 kDa immunophilin antibody; 52 kDa FKBP antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of FKBP52 recombinant protein (Accession Number: NM_002014). Purification method: Protein G purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:107218(FKBP52 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human appendix using Catalog No:107218(FKBP52 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human appendix using Catalog No:107218(FKBP52 antibody) at dilution of 1:100 (under 40x lens)
Immunofluorescent analysis of Hela cells, using FKBP4 antibody Catalog No: at 1:50 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
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Background
FKBP52 (FK506 binding protein 4) is a member of the immunophilin protein family that comprises intracellular protein effectors of immunosuppressive drugs, and it is known as a steroid receptor-associated protein. As a novel regulator of microtubule dynamics, FKBP52 is associated with the motor protein dynein and with the cytoskeleton during mitosis. FKBP52 is highly expressed in CNS regions susceptible to Alzheimer's, and plays a role in modulating toxicity of Abeta peptides. The protein can associate with the Tau function, and may help to decipher and modulate the events involved in Tau-induced neurodegeneration. In addition, FKBP52 is likely to play a role in growth and development of the male genitalia.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"