FKBP52 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, Jurkat cells, NIH/3T3 cells, PC-3 cells. Positive IF detected in MCF-7 cells. Positive IHC detected in human prostate cancer tissue. Positive FC detected in MCF-7 cells. Observed molecular weight by Western-blot: 56-59 kDa
ELISA, WB, IHC, IF, IP, FC
Human, Mouse; other species not tested.
51 kDa FK506 binding protein antibody; 52 kDa FK506 binding protein antibody; 52 kDa FKBP antibody; 59 kDa immunophilin antibody; FK506 binding protein 4 antibody; FK506 binding protein 4 antibody; 59kDa antibody; FKBP 4 antibody; FKBP 52 antibody; FKBP4 antibody; FKBP51 antibody; FKBP52 antibody; FKBP59 antibody; HBI antibody; HSP binding immunophilin antibody; Hsp56 antibody; Immunophilin FKBP52 antibody; p52 antibody; p59 antibody; PPIase antibody; PPIase FKBP4 antibody; Rotamase antibody
This antibody was obtained by immunization of FKBP52 recombinant protein (Accession Number: BC007924). Purification method: Antigen affinity purified.
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:110676(FKBP52 antibody) at dilution of 1:1000
IP Result of anti-FKBP52 (IP:Catalog No:110676, 3ug; Detection:Catalog No:110676 1:1000) with HeLa cells lysate 3000ug.
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110676(FKBP52 antibody) at dilution of 1:100 (under 25x lens)
Immunofluorescent analysis of MCF-7 cells, using FKBP4 antibody Catalog No:110676 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
1X10^6 MCF-7 cells were stained with 0.2ug FKBP52 antibody (Catalog No:110676, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.
FKBP52 (FK506 binding protein 4) is a member of the immunophilin protein family that comprises intracellular protein effectors of immunosuppressive drugs, and it is known as a steroid receptor-associated protein. As a novel regulator of microtubule dynamics, FKBP52 is associated with the motor protein dynein and with the cytoskeleton during mitosis. FKBP52 is highly expressed in CNS regions susceptible to Alzheimer's, and plays a role in modulating toxicity of Abeta peptides. The protein can associate with the Tau function, and may help to decipher and modulate the events involved in Tau-induced neurodegeneration. In addition, FKBP52 is likely to play a role in growth and development of the male genitalia.
- Martinez NJ, Chang HM, Borrajo Jde R, Gregory RI. The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA (New York, N.Y.). 19(11):1583-93. 2013.
- Desmetz C, Bascoul-Mollevi C, Rochaix P. Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women. Clinical cancer research : an official journal of the American Association for Cancer Research. 15(14):4733-41. 2009.
- Soontornniyomkij V, Risbrough VB, Young JW. Short-term recognition memory impairment is associated with decreased expression of FK506 binding protein 51 in the aged mouse brain. Age (Dordrecht, Netherlands). 32(3):309-22. 2010.
- Soontornniyomkij V, Everall IP, Moore DJ. Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. Journal of neurovirology. 18(4):313-22. 2012.
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