Mouse FDPS / Farnesyl Diphosphate Synthase (His Tag) recombinant protein

Mouse FDPS / Farnesyl Diphosphate Synthase (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.

Fdps protein

AI256750; GERANYLTRANSTRANSFERASE; FPPS; FPP SYNTHETASE; MKIAA1293; FPP SYNTHASE; FARNESYL PYROPHOSPHATE SYNTHASE; FARNESYL PYROPHOSPHATE SYNTHETASE; 6E)-FARNESYL DIPHOSPHATE SYNTHASE; DIMETHYLALLYLTRANSTRANSFERASE; 6030492I17RIK; FDPSL1; FPS

Q920E5

Fdps; mCG_17543

E. coli

A DNA sequence encoding the mouse Fdps (NP_608219.1) (Met1-Lys353) was expressed with a polyhistidine tag at the N-terminus.

Mouse

The recombinant mouse Fdps consists 371 amino acids and predicts a molecular mass of 42.8 kDa.

> 85 % as determined by SDS-PAGE.