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Product Name
FDPS antibody
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Description
FDPS Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HepG2 cells, human cerebellum tissue, human spleen tissue, MCF7 cells, mouse liver tissue, rat liver tissue. Positive IP detected in mouse liver tissue. Observed molecular weight by Western-blot: 39-41 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FDPS antibody; FPP synthase antibody; FPPS antibody; FPS antibody; KIAA1293 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of FDPS recombinant protein (Accession Number: NM_002004). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:110608(FDPS antibody) at dilution of 1:1500
IP Result of anti-FDPS (IP:Catalog No:110608, 4ug; Detection:Catalog No:110608 1:1000) with mouse liver tissue lysate 4000ug.
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Background
FPPS (also known as FDPS) is a key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. The expression of FPPS was elevated in prostate tumor cell lines, indicating its potential role in prostate cancer progression. Western blot analysis using this antibody detected a major band around 41kD in mouse liver tissue.
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References
- Yang J, Zhu HH, Chen GP. Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo. The international journal of biochemistry & cell biology. 45(3):657-66. 2013.
- Yang J, Zhao CZ, Chen B, Chen F, Han J, Hu SJ. Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice. BioMed research international. 2015:914026. 2015.
- Yang J, Mou Y, Wu T. Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice. Cardiovascular research. 97(3):490-9. 2013.
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