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Product Name
Anti-FDPS / Farnesyl Diphosphate Synthase antibody
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Description
Rabbit polyclonal to FDPS / Farnesyl Diphosphate Synthase
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Tested applications
WB, IHC-P, IP
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Species reactivity
Mouse FDPS / Farnesyl Diphosphate Synthase
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Alternative names
FPS antibody; FPPS antibody; Fdpsl1 antibody; AI256750 antibody; mKIAA1293 antibody; 6030492I17Rik antibody; dimethylallyltranstransferase antibody; farnesyl pyrophosphate synthase antibody; farnesyl pyrophosphate synthetase antibody; FPP synthase antibody; FPP synthetase antibody; geranyltranstransferase antibody; 6E)-farnesyl diphosphate synthase antibody; FPPS antibody; FPS antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse FDPS / Farnesyl Diphosphate Synthase (rh FDPS / Farnesyl Diphosphate Synthase; NP_608219.1; Met1-Lys353). FDPS / Farnesyl Diphosphate Synthase specific IgG was purified by Mouse FDPS / Farnesyl Diphosphate Synthase affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/mL
IHC-P: 0.1-1 μg/mL
IP: 1-4 μg/mg of lysate
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Validations
FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of mouse FDPS in mouse kidney with rabbit polyclonal antibody (0.3 µg/mL, formalin-fixed paraffin embedded sections).
FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.
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References
- Pjetursson BE, et al. (2007) Comparison of survival and complication rates of tooth-supported fixed dental prostheses (FDPs) and implant-supported FDPs and single crowns (SCs). Clin Oral Implants Res. 3:97-113.
- Eschbach S, et al. (2009) Clinical evaluation of all-ceramic posterior three-unit FDPs made of In-Ceram Zirconia. Int J Prosthodont. 22(5):490-2.
- Moshage HJ, et al. (1990) Differential effects of endotoxin and fibrinogen degradation products (FDPS) on liver synthesis of fibrinogen and albumin: evidence for the involvement of a novel monokine in the stimulation of fibrinogen synthesis induced by FDPS. Int J Biochem. 22(12): 1393-400.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"