Human Fractalkine/CX3CL1 (His Tag) recombinant protein
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.
Chemokine (C-X3-C motif) ligand 1
Protein short names
D8BWG0439E; CXC3; CXC3C; ABCD-3; CX3C; C3XKINE; CX3CL1; SCYD1; NEUROTACTIN; AB030188; NTN; AI848747; FRACTALKINE; NTT
A DNA sequence encoding the human CX3CL1 (NP_002987.1) extracellular domain (Met 1-Arg 339) with a C-terminal polyhistidine tag was expressed.
The secreted recombinant human CX3CL1 comprises 329 amino acids with a predicted molecular mass of 35 kDa. As a result of different glycosylation, rhCX3CL1 migrates between 50-70 kDa in SDS-PAGE under reducing conditions.
> 95 % as determined by SDS-PAGE
Measured by its ability to compete with biotinylated recombinant human CX3CL1-His for binding to immobilized recombinant mouse CD4-his (Cat:503011）in a functional ELISA.
Human Fractalkine / CX3CL1 Protein (His Tag) SDS-PAGE
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