Canine Fractalkine/CX3CL1 (Fc Tag) recombinant protein
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.
Chemokine (C-X3-C motif) ligand 1
Protein short names
ABCD-3; CXC3C; C3XKINE; CX3C; CXC3; D8BWG0439E; NTT; FRACTALKINE; AI848747; AB030188; NTN; SCYD1; CX3CL1; NEUROTACTIN
A DNA sequence encoding the canine CX3CL1 (H1ADY9) (Met1-Arg379) was expressed with the Fc region of human IgG1 at the C-terminus.
The recombinant canine CX3CL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 596 amino acids and has a predicted molecular mass of 64.4 kDa. The apparent molecular mass of the protein is approximately 70-100 kDa in SDS-PAGE under reducing conditions due to glycosylation.
> 95 % as determined by SDS-PAGE
Canine Fractalkine / CX3CL1 Protein (Fc Tag) SDS-PAGE
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