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Product Name
Mouse Cx3cl1/Cx3c/Fkn/Scyd1 (His tag) recombinant protein
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Description
Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glycoprotein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17/tumor necrosis factor-α-converting enzyme (ADAM17/TACE) participate in this shedding. It has been suggested that ADAM10 acts in the constitutive shedding, and ADAM17 acts in response to cell activation. The protein may play a role in regulating leukocyte adhesion and migration processes at the endothelium.
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Protein name
chemokine (C-X3-C motif) ligand 1(Cx3cl1)
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Protein short names
Cx3c; Fkn; Scyd1
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Uniprot ID
O35188
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Cx3cl1/Cx3c/Fkn/Scyd1 Gln25-Arg337 is expressed with a 6His tag at the C-terminus.
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Protein Species
Mouse
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Purity
>95% as determined by SDS-PAGE.
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Validations
Mouse Cx3cl1/Cx3c/Fkn/Scyd1 (His tag) recombinant protein
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