Rhesus CD27 (Fc Tag) recombinant protein

Cat.#: 501020

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Product Information

  • Product Name
    Rhesus CD27 (Fc Tag) recombinant protein
  • Documents
  • Description
    CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.
  • Protein name
    CD27L receptor
  • Protein short names
    T14; MGC20393; TP55; TNFRSF7; CD27; S152; S152.LPFS2
  • Uniprot ID
    F7BYS2
  • Gene Name
    CD27; EGK_03271
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rhesus CD27 (XP_001104337.1) (Met1-Ile192) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus comprises 413 amino acids and has a calculated molecular mass of 46.3 KDa.
  • Purity
    (87.6+8.4) % as determined by SDS-PAGE
  • Activity
    Immobilized Rhesus CD27-Fc at 10 μg/ml (100 μl/well) can bind biotinylated human CD70-Fc (Cat:502332), The EC50 of biotinylated human CD70-Fc (Cat:502332) is 10.9-25.3 ng/ml.
  • Validations

    Cynomolgus CD27 / TNFRSF7 Protein (Fc Tag) SDS-PAGE

    Cynomolgus CD27 / TNFRSF7 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"