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Product Name
Human CD27 (His & Fc Tag) recombinant protein
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Description
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
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Protein name
CD27 antigen
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Protein short names
TNFRSF7; MGC20393; T14; TP55; CD27; S152; S152.LPFS2
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Uniprot ID
P26842
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Gene Name
CD27; TNFRSF7
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Ile 192) of human CD27 (NP_001233.1) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the carboxy-terminus.
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Protein Species
Human
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Molecular weight
The recombinant mature human CD27/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 420 amino acids and has a calculated molecular mass of 47.2 kDa. As a result of glycosylation, the monomer migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind with recombinant human CD70.
Immobilized recombinant human CD27 at 2 μg/ml (100 μl/well) can bind biotinylated human CD70 with a linear range of 0.39-12.5 ng/ml. -
Validations
Human CD27 / TNFRSF7 Protein (His & Fc Tag) SDS-PAGE
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