Anti-UCHL1 antibody

Anti-UCHL1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to UCHL1

ELISA, WB, IP

Rat UCHL1

AW822034 antibody; C88048 antibody; gad antibody; PARK5 antibody; PGP 9.5 antibody; PGP 9.5 antibody; PGP9.5 antibody; PGP9.5 antibody; PGP95 antibody; R75593 antibody; Uchl1 antibody; UCHL1 antibody; UCH-L1 antibody; Uch-L1 antibody; NDGOA antibody; PARK5 antibody; PGP95 antibody; PGP9.5 antibody; Uch-L1 antibody; HEL-117 antibody; gad antibody; C88048 antibody; PGP9.5 antibody; R75593 antibody; UCH-L1 antibody; UCHL-1 antibody; AW822034 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Rat UCHL1 (rR UCHL1; Q00981; Glu2-Ala223).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in synaptic strength. UCHL1 is found in neuronal cell bodies and processes throughout the neocortex (at protein level). It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 is weakly expressed in ovary. UCHL1 is a ubiquitin-protein hydrolase. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. Reduced UCHL1 function may jeopardize the survival of CNS neurons.

• Wada H., et al., 1998, Biochem. Biophys. Res. Commun. 251:688-92.
• Choi J., et al., 2004, J. Biol. Chem. 279:13256-64.
• Lombardino,A.2005, et al., J.Proc Natl Acad Sci.USA102 (22):8036-41
• Okochi-Takada,E. et al., 2006, Int J Cancer. 119 (6):1338-44.
• Zetterberg, M. et al., 2010, Mol Neurodegener  5 :11.