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  • Anti-GRP78 BiP Rabbit antibody

Anti-GRP78 BiP Rabbit antibody

Cat.#: 168935

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Product Information

  • Product Name
    Anti-GRP78 BiP Rabbit antibody
  • Documents
  • Description
    GRP78 BiP Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    BIP; MIF2; GRP78; HEL-S-89n antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human GRP78 BiP
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000-1/5000

    IHC: 1/50-1/200

  • Validations

    Western blot detection of GRP78 BiP in C6 cell lysates using GRP78 BiP Rabbit mAb(1:1000 diluted).Predicted band size:72kDa.Observed band size:78kDa.

    Western blot detection of GRP78 BiP in C6 cell lysates using GRP78 BiP Rabbit mAb(1:1000 diluted).Predicted band size:72kDa.Observed band size:78kDa.

  • Background
    Swiss-Prot Acc.P11021.Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate . Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 . Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 . Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"