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Product Name
Anti-Cytokeratin 18 Rabbit antibody
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Description
Cytokeratin 18 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC
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Species reactivity
Human, Rat
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Alternative names
K18; CK-18; CYK18 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Cytokeratin 18
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000
IHC: 1/50
ICC/IF: 1/50
FC: 1/20
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Validations
Immunocytochemistry of Cytokeratin 18(green) in Hela cells using Cytokeratin 18 Rabbit pAb at dilution 1/50, and DAPI(blue)
Western blot detection of Cytokeratin 18 in K562,Hela cell lysates using Cytokeratin 18 Rabbit pAb(1:1000 diluted).Predicted band size:48kDa.Observed band size:48kDa.
Immunohistochemistry of Cytokeratin 18 in paraffin-embedded Human colon cancer tissue using Cytokeratin 18 Rabbit pAb at dilution 1/50
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Background
Swiss-Prot Acc.P05783.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells . When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"