Cart 2

Anti-CD45 Mouse antibody

Cat.#: 168510

Size:

Special Price 441.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-CD45 Mouse antibody
  • Documents
  • Description
    CD45 Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli.
  • Clonality
    Monoclonal
  • Formulation
    Purified antibody in PBS with 0.05% sodium azide
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    IHC: 1/200 - 1/1000

    ELISA: 1/10000

  • Validations

    Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using PTPRC mouse mAb with DAB staining.

    Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using PTPRC mouse mAb with DAB staining.

    Immunohistochemical analysis of paraffin-embedded breast cancer tissues using PTPRC mouse mAb with DAB staining.

    Immunohistochemical analysis of paraffin-embedded breast cancer tissues using PTPRC mouse mAb with DAB staining.

    Western blot analysis using PTPRC mAb against human PTPRC (AA: 928-989) recombinant protein. (Expected MW is 33 kDa)

    Western blot analysis using PTPRC mAb against human PTPRC (AA: 928-989) recombinant protein. (Expected MW is 33 kDa)

    Western blot analysis using PTPRC mAb against HEK293 (1) and PTPRC (AA: 928-989)-hIgGFc transfected HEK293 (2) cell lysate.

    Western blot analysis using PTPRC mAb against HEK293 (1) and PTPRC (AA: 928-989)-hIgGFc transfected HEK293 (2) cell lysate.

    Western blot detection of Anti-PTPRC Mouse mAb in Ramos,Raw264.7 cell lysates using Anti-PTPRC Mouse mAb(1:1000 diluted).Predicted band size:147.3KDa.Observed band size:180 to 240KDa.

    Western blot detection of Anti-PTPRC Mouse mAb in Ramos,Raw264.7 cell lysates using Anti-PTPRC Mouse mAb(1:1000 diluted).Predicted band size:147.3KDa.Observed band size:180 to 240KDa.

  • Background
    Swiss-Prot Acc.P08575.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"