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  • Anti-Caspase-8 Rabbit antibody

Anti-Caspase-8 Rabbit antibody

Cat.#: 168890

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Product Information

  • Product Name
    Anti-Caspase-8 Rabbit antibody
  • Documents
  • Description
    Caspase-8 Rabbit monoclonal antibody
  • Tested applications
    WB, ICC/IF, FC
  • Species reactivity
    Human
  • Alternative names
    CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Caspase-8
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    ICC/IF: 1/20

    FC: 1/20

  • Validations

    Western blot detection of Caspase-8 in CHO-K1 cell lysates using Caspase-8 Rabbit mAb(1:500 diluted).Predicted band size:55kDa.Observed band size:55kDa.

    Western blot detection of Caspase-8 in CHO-K1 cell lysates using Caspase-8 Rabbit mAb(1:500 diluted).Predicted band size:55kDa.Observed band size:55kDa.

  • Background
    Swiss-Prot Acc.Q14790.Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"