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  • Human Caspase 8 Recombinant protein (GST tag)

Human Caspase 8 Recombinant protein (GST tag)

Cat.#: 506184

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Product Information

  • Product Name
    Human Caspase 8 Recombinant protein (GST tag)
  • Documents
  • Description
    Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. {PubMed:23516580, PubMed:9006941}.
  • Protein name
    Caspase-8
  • Protein short names
    MCH5
  • Uniprot ID
    Q14790
  • Gene Name
    CASP8; MCH5
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1-270 aa encoded by BC028223 was inserted into PGEX-4T vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human Caspase 8 SDS-PAGE

    Recombinant human Caspase 8 SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"