Anti-Bcl-2 Rabbit antibody

Cat.#: 167316

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Bcl-2 Rabbit antibody
  • Documents
  • Description
    Bcl-2 Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human, Mouse
  • Alternative names
    Bcl-2; PPP1R50 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human Bcl-2
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    IHC: 1/20-1/500

    ICC/IF: 1/20

    FC: 1/50

  • Validations

    Western blot detection of Bcl-2 in MCF-7 cell lysates using Bcl-2 Rabbit pAb(1:1000 diluted).Predicted band size:26KDa.Observed band size:26KDa.

    Western blot detection of Bcl-2 in MCF-7 cell lysates using Bcl-2 Rabbit pAb(1:1000 diluted).Predicted band size:26KDa.Observed band size:26KDa.

    Western blot detection of Bcl-2 in K562,CHO-K1,3T3,Hela cell lysates using Bcl-2 Rabbit pAb(1:1000 diluted).Predicted band size:26KDa.Observed band size:26KDa.

    Western blot detection of Bcl-2 in K562,CHO-K1,3T3,Hela cell lysates using Bcl-2 Rabbit pAb(1:1000 diluted).Predicted band size:26KDa.Observed band size:26KDa.

    Immunohistochemistry of Bcl-2 in paraffin-embedded Human breast cancer tissue using Bcl-2 Rabbit pAb at dilution 1/100

    Immunohistochemistry of Bcl-2 in paraffin-embedded Human breast cancer tissue using Bcl-2 Rabbit pAb at dilution 1/100

  • Background
    Swiss-Prot Acc.P10415.Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"