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Mouse B7-H4/B7S1/B7x (Fc Tag) recombinant protein

Cat.#: 501081

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Product Information

  • Product Name
    Mouse B7-H4/B7S1/B7x (Fc Tag) recombinant protein
  • Documents
  • Description
    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
  • Protein name
    V-set domain containing T-cell activation inhibitor 1
  • Protein short names
    IMMUNE COSTIMULATORY PROTEIN B7-H4; B7H4; T CELL COSTIMULATORY MOLECULE B7X; B7S1; BC032925; V-SET DOMAIN CONTAINING T-CELL ACTIVATION INHIBITOR 1; B7X
  • Uniprot ID
    Q7TSP5
  • Gene Name
    Vtcn1; B7h4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of mouse B7H4 (Q7TSP5) (phe 29-Ser 256) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse B7H4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 469 amino acids and has a calculated molecular mass of 52.2 kDa. The apparent molecular mass of rmB7H4/Fc monomer is approximately 70-75 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Mouse B7-H4 / B7S1 / B7x Protein (Fc Tag) SDS-PAGE

    Mouse B7-H4 / B7S1 / B7x Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"