Mouse B7-H4/B7S1/B7x recombinant protein

Mouse B7-H4/B7S1/B7x recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.

V-set domain containing T-cell activation inhibitor 1

V-SET DOMAIN CONTAINING T-CELL ACTIVATION INHIBITOR 1; B7X; T CELL COSTIMULATORY MOLECULE B7X; B7S1; BC032925; IMMUNE COSTIMULATORY PROTEIN B7-H4; B7H4

Q7TSP5

Vtcn1; B7h4

Human Cells

A DNA sequence encoding the mouse Vtcn1 (Q7TSP5) (Phe29-Ser256) was expressed with six amino acids (LEVLFQ) at the C-terminus.

Mouse

The recombinant mouse Vtcn1 consists 235 amino acids and predicts a molecular mass of 26 kDa.

> 90 % as determined by SDS-PAGE.