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Product Name
Cynomolgus TNF-alpha/TNFA recombinant protein
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Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
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Protein name
Tumor necrosis factor
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Protein short names
TNFSF2; DADB-70P7.1; TNFA; TNFSF1A; DIF; TNF-A; TNF-ALPHA; TNFALPHA; MGC151434; TNF
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Uniprot ID
P79337
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Gene Name
TNF; TNFA; TNFSF2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus TNF (NP_001272206.1) (Val 77-Leu233) was expressed and purified with an initial Met.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus TNF consists of 158 amino acids and has a calculated molecular mass of 17.4 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Activity
Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D.
The ED50 for this effect is typically 1-5 ng/ml. -
Validations
Cynomolgus TNF-alpha / TNFA Protein SDS-PAGE
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