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Product Name
Human TNF-alpha/TNFA (Fc Tag) recombinant protein
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Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
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Protein name
Tumor necrosis factor
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Protein short names
TNF-A; TNFA; TNFALPHA; TNF-ALPHA; TNFSF2; DIF; TNFSF1A; MGC151434; TNF; DADB-70P7.1
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Uniprot ID
Q5STB3
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Gene Name
TNF; TNFA; TNFSF2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human TNF (NP_000585.2) (Val77-Leu233) was expressed with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human TNF consists 417 amino acids and predicts a molecular mass of 45.8 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Human TNF-alpha / TNFA Protein (Fc Tag)
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