STAT3 antibody

STAT3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

STAT3 Mouse Monoclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in Hela cells, Jurkat cells, RAW 264.7 cells. Positive IHC detected in human lung cancer tissue, human breast cancer tissue, human cervical cancer tissue, human heart tissue, human liver tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 88 kDa

ELISA, WB, IHC, IP, IF

Human,Mouse, Rat; other species not tested.

Acute phase response factor antibody; APRF antibody; FLJ20882 antibody; HIES antibody; STAT3 antibody

Mouse IgG2a

This antibody was obtained by immunization of STAT3 recombinant protein (Accession Number: XM_017024975). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. This antibody is a mouse monoclonal antibody raised against residues near the N terminus of human STAT3.

• Wang SJ, Cui HY, Liu YM. CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells. Oncotarget. 6(1):243-57. 2015.