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Product Name
Anti-STAT3 (4C8) Mouse antibody
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Description
STAT3 (4C8) Mouse monoclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat, Monkey, Hamster
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Alternative names
1110034C02Rik;Acute Phase Response Factor;Acute-phase response factor;APRF;AW109958;DNA binding protein APRF;FLJ20882;HIES;MGC128731; MGC16063;MGC93551;Signal transducer and activator of transcription 3 (acute-phase response factor);Signal transducer and antibody
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Isotype
Mouse IgG1
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Preparation
Antigen: Purified recombinant human STAT3 protein fragments expressed in E.coli
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Clonality
Monoclonal
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Formulation
Ascites containing with 0.03% Proclin300 and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of STAT3 in CHO-K1,C6,3T3,K562,CEM,Jurkat,Hela,MCF7,COS7,293T,A431 and A549 cell lysates using STAT3 mouse mAb (1:1000 diluted).Predicted band size:88KDa.Observed band size:88KDa.
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Background
Swiss-Prot Acc.P40763.Signal transducer and transcription activator that mediates cellular responses to interleukins,KITLG/SCF and other growth factors.May mediate cellular responses to activated FGFR1,FGFR2,FGFR3 and FGFR4.Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.Activated by IL31 through IL31RA.Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G by similarity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"