Rhesus PDGFRB/CD140b (His Tag) recombinant protein

Rhesus PDGFRB/CD140b (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.

Platelet-derived growth factor receptor beta

IBGC4; PDGFR; PDGFR1; CD140B; IMF1; AI528809; PDGFRB; PDGFR-1; JTK12

F7BTH1

PDGFRB

Human Cells

A DNA sequence encoding the rhesus PDGFRB (XP_001107595.1) (Met1-Phe530) was expressed with a polyhistidine tag at the C-terminus.

Rhesus

The recombinant rhesus PDGFRB comprises 509 amino acids and has a calculated molecular mass of 57.7 Kda.

> 95 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized Rhesus PDGFRB-His at 10 μg/ml (100 μl/well) can bind Rhesus PDGFB (Cat:502517), The EC₅₀ of Rhesus PDGFB (Cat:502517) is 3-8 ng/ml.