Human PDGFRB/CD140b (His & Fc Tag) recombinant protein

Human PDGFRB/CD140b (His & Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.

Platelet-derived growth factor receptor beta

AI528809; PDGFR-1; PDGFRB; JTK12; IBGC4; PDGFR; PDGFR1; CD140B; IMF1

Q59F04

PDGFRB; PDGFR; PDGFR1

Human Cells

A DNA sequence encoding the human PDGFR? (NP_002600.1) extracellular domain (Met 1-Lys 531) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Human

The secreted recombinant human PDGFR?/Fc is a disulfide-linked homodimer. The reduced monomer comprises 747 amino acids and predicts a molecular mass of 84.2 kDa. It migrates as an approximately 125-135 kDa band in SDS-PAGE under reducing conditions due to glycosylation.

> 70 % as determined by SDS-PAGE