Human PDGFRB recombinant protein (C-His)

Cat.#: 514794

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Product Information

  • Product Name
    Human PDGFRB recombinant protein (C-His)
  • Documents
  • Description
    The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein name
    Platelet-derived growth factor receptor beta
  • Protein short names
    CD140B,IBGC4,IMF1,JTK12,KOGS,PDGFR,PDGFR-1,PDGFR1,PENTT
  • Uniprot ID
    P09619
  • Gene Name
    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; EC 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD antigen CD140b
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human PDGFRβ (NP_002600.1) extracellular domain (Met1-Lys531) was expressed, with a C-terminal polyhistidine tag. The expressed protein was biotinylated in vitro.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human PDGFRβ comprises 510 amino acids and predicts a molecular mass of 57.6 kDa.
  • Purity
    > 95% as determined by SDS-PAGE.
  • Activity
    1.Measured by its binding ability in a functional ELISA.
    2.Immobilized biotinylated human PDGFRb-His (Cat:10514-H08H-B) at 10μg/mL (100μL/well) can bind Cynomolgus PDGFB-Fc(Cat:90030-C04H), The EC50 of Cynomolgus PDGFB-Fc is 30-80ng/mL.
  • Validations

    Human PDGFRB/CD140b Protein 15501

    Human PDGFRB/CD140b Protein 15501

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"