Human PDGFRB recombinant protein (C-His)

Human PDGFRB recombinant protein (C-His)

• DataSheet
• Material Safety Data Sheets (MSDS)

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy

Platelet-derived growth factor receptor beta

CD140B,IBGC4,IMF1,JTK12,KOGS,PDGFR,PDGFR-1,PDGFR1,PENTT

P09619

Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; EC 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD antigen CD140b

Human Cells

A DNA sequence encoding the human PDGFRβ (NP_002600.1) extracellular domain (Met1-Lys531) was expressed, with a C-terminal polyhistidine tag. The expressed protein was biotinylated in vitro.

Human

The recombinant human PDGFRβ comprises 510 amino acids and predicts a molecular mass of 57.6 kDa.

> 95% as determined by SDS-PAGE.

1.Measured by its binding ability in a functional ELISA.
2.Immobilized biotinylated human PDGFRb-His (Cat:10514-H08H-B) at 10μg/mL (100μL/well) can bind Cynomolgus PDGFB-Fc(Cat：90030-C04H), The EC₅₀ of Cynomolgus PDGFB-Fc is 30-80ng/mL.